Potent Cyclic Tetrapeptide for Lead Detoxification

Lead (Pb) is a ubiquitous poisonous metal, affecting the health of vast populations worldwide. Medications to treat Pb poisoning suffer from various limitations and are often toxic owing insufficient metal selectivity. Here, we report cyclic tetrapeptide that selectively binds eradicates its effect on cellular level, with superior potency than state-of-the-art drugs. The Pb-peptide complex remarkably strong was characterized experimentally computationally. Accompanied by lack toxicity enhanced stability this peptide, these qualities indicate merit as potential remedy for poisoning.